• Srinivasulu Yerukala Sathipati PhD

  • Associate Research Scientist


    • MCRI - MCRI-Precision Med Research
    • 1000 North Oak Ave. MLR Marshfield, WI 54449
    • (715) 221-6470

Education

2017:
PhD, Bioinformatics and Systems biology, National Yang Ming Chiao Tung University (formerly National Chiao Tung University), Hsinchu, Taiwan
2008:
MSc, Bioinformatics, Sri Venkateswara University, Tirupati, Andhrapradesh, India
2006:
BSc, Biotechnology, Sri Krishnadevaraya University, Andhrapradesh, India

Work Experience

2021 to Present:
Associate Research Scientist, Marshfield Clinic Research Institute, Marshfield, WI
2017 to 2021:
Postdoctoral Fellow, National Chiao Tung University, Hsinchu, Taiwan

Statement

Today, the concept of precision medicine requires knowledge in multiple fields such as bioinformatics, machine learning and artificial intelligence. My research focuses on applications of bioinformatics in cancer research with the goal of identifying important biomarkers in various cancers which would help in biomarker discovery and personalized medicine. I am interested in developing novel computational methods for identifying gene signatures for early stage detection and survival estimation in patients with various cancers using bioinformatics/machine learning techniques. My long-standing aim is to be actively involved in bioinformatics which would bring fresh insights into the precision medicine research.

Research Interests

• Developing non-invasive early stage detection of cancers using Artificial intelligence
• Identifying cancer biomarkers for diagnosis, prognosis and treatment response
• Integrating bioinformatics and omics data to establish a biomarker signature platform which provides important biomarker signatures associated with various cancers
• Applications of Machine learning/Artificial intelligence in multidisciplinary areas, including bioinformatics, cancer research, precision medicine, neurological diseases and COVID-19

Select Publications

  • Yerukala Sathipati S, Tsai MJ, Aimalla N, Moat L, Shukla SK, Allaire P,...Ho SY [including Hebbring S, Sharma R.] An evolutionary learning-based method for identifying a circulating miRNA signature for breast cancer diagnosis prediction. NAR Genom Bioinform. 2024 March;6(1):lqae022. doi: 10.1093/nargab/lqae022. PMCID: PMC10894035.
    PubMed ID: 38406797
  • Sathipati, SY, Jeong, S, Sharma, P, Mayer, J, Sharma, R, Ho, S, Hebbring, S. Exploring prognostic implications of miRNA signatures and telomere maintenance genes in kidney cancer. Molecular Therapy: Oncology. 2024 December 19;32(4):200874. doi: 10.1016/j.omton.2024.200874.
  • Yerukala Sathipati, S, Carter, T, Soodi, D, Somto, N, Shukla, SK, Petronovich, J,...Sharma, P [including Glurich, I.] MicroRNA signature predicts post-operative atrial fibrillation after coronary artery bypass grafting. [published online ahead of print 2024 June 22]. MedRxIV. doi: 10.1101/2024.06.21.24309328.
  • Yerukala Sathipati S,, Sharma, PP, Shukla, S, Carter, T, Soodi, D, Nwaedozie, ST,...Glurich, I. CIRCULATING MICRORNA SIGNATURE PREDICTS ATRIAL FIBRILLATION IN PATIENTS FOLLOWING CORONARY ARTERY BYPASS GRAFTING. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2024 April 2;83(13):33. doi: 10.1016/S0735-1097(24)02023-0.
  • Sharma, PP, Yerukala Sathipati , Shukla, S, Carter, T, Soodi, D. IDENTIFICATION OF A MICRORNA SIGNATURE FOR PREDICTING ATRIAL FIBRILLATION IN PATIENTS WITH VALVULAR HEART DISEASE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2024 April 2;83(13):2185. doi: 10.1016/S0735-1097(24)04175-5.
  • Yerukala Sathipati S,, Sharma, R, Hebbring, S. Abstract 4892: MicroRNA signature and telomere genes in kidney cancer survival. CANCER RESEARCH. 2024 March;84(6_Supplement):4892-4892. doi: 10.1158/1538-7445.AM2024-4892.
  • Yerukala Sathipati S, Ming-Ju T, Shukla S, Shinn-Ying H. Artificial intelligence-driven pan-cancer analysis reveals miRNA signatures for cancer stage prediction. Human Genetics and Genomics Advances. 2023 July;4(3):100190. doi: 10.1016/j.xhgg.2023.100190. PMCID: PMC10130501.
    PubMed ID: 37124139
  • Yerukala Sathipati S, Shinn-Ying H. Survival associated miRNA signature in patients with head and neck carcinomas. Heliyon. 2023 June 11;9(6):E17218. doi: doi.org/10.1016/j.heliyon.2023.e17218. PMCID: PMC10285236.
    PubMed ID: 37360084
  • Yerukala Sathipati S, Aimalla N, Tsai MJ, Carter T, Jeong S, Wen Z,...Ho SY [including Shukla SK.] Prognostic microRNA signature for estimating survival in patients with hepatocellular carcinoma. CARCINOGENESIS. 2023 December 2;44(8-9):650-661. doi: 10.1093/carcin/bgad062.
    PubMed ID: 37701974
  • Carter T, Valenzuela RK, Yerukala Sathipati S, Medina-Flores R. Gene signatures associated with prognosis and chemotherapy resistance in glioblastoma treated with temozolomide. Frontiers in Genetics. 2023 December 18;14(2023). doi: 10.3389/fgene.2023.1320789. PMCID: PMC10802164.
    PubMed ID: 38259614
  • Srinivasulu Yerukala Sathipati, Ming-Ju Tsai, Shukla, Sanjay K, Shinn-Ying Ho, Yi Liu, Afshin Behesthi. MicroRNA signature for estimating the survival time in patients with bladder urothelial carcinoma. Scientific Reports. 2022 March 9;12(4141).
  • Yerukala Sathipati S, Tsai MJ, Shukla SK, Ho SY, Liu Y, Beheshti A. Author Correction: MicroRNA signature for estimating the survival time in patients with bladder urothelial carcinoma. Sci Rep. 2022 March 23;12(1):4990. doi: 10.1038/s41598-022-09235-4. PMCID: PMC8943119.
    PubMed ID: 35322184
  • Yerukala Sathipati S, Tsai MJ, Carter T, Allaire P, Shukla SK, Beheshti A, Ho SY. Survival estimation in patients with stomach and esophageal carcinoma using miRNA expression profiles. Computational and Structural Biotechnology Journal. 2022 August 20;20(2022):4490-4500. doi: https://doi.org/10.1016/j.csbj.2022.08.025. PMCID: PMC9421182.
    PubMed ID: 36051876
  • Yerukala Sathipati S, Tsai MJ, Carter TC, Sanjay SK, Ho SY. SPIKES: Identification of physicochemical properties of spike proteins across diverse host species of SARS-CoV-2. STAR Protocols. 2022 September;3(3):101460. doi: 10.1016/j.xpro.2022.101460. PMCID: PMC9127179.
    PubMed ID: 35726315
  • Yerukala Sathipati S, Shukla SK, Ho SY. Tracking the amino acid changes of spike proteins across diverse host species of severe acute respiratory syndrome coronavirus 2. iScience. 2022 January 21;25(1):103560. doi: 10.1016/j.isci.2021.103560. PMCID: PMC8638202.
    PubMed ID: 34877480
  • Yerukala Sathipati S, Ho SY. Identification of the miRNA signature associated with survival in patients with ovarian cancer. Aging (Albany NY). 2021 May 15;13(9):12660-12690. doi: 33910165. PMCID: PMC8148489.
    PubMed ID: 33910165
  • Yerukala Sathipati, S. Identification and Characterization of Species-Specific Severe Acute Respiratory Syndrome Coronavirus 2 Physicochemical Properties. ACS Chem. Biol.. 2021 April 15;20(5):2942-2952. doi: 10.1021/acs.jproteome.1c00156. PMCID: PMC8056951.
    PubMed ID: 33856796
  • Lin Y, Yerukala Sathipati S, Ho SY. Predicting the Risk Genes of Autism Spectrum Disorders. Front Genet. 2021 June 14; 12 :665469. doi: 10.3389/fgene.2021.665469. PMCID: PMC8236850.
    PubMed ID: 34194469
  • Srinivasulu Yerukala Sathipati, Shinn-Ying Ho. Identification and Characterization of Species-Specific SARS-CoV-2 Physicochemical Properties. [published online ahead of print 2020 September 24]. SSRN Electronic Journal. doi: 10.2139/ssrn.3677481 .
  • Yerukala Sathipati S, Ho SY. Novel miRNA signature for predicting the stage of hepatocellular carcinoma. Sci Rep. 2020 September 2; 10(1):14452. doi: 10.1038/s41598-020-71324-z. PMCID: PMC7467934.
    PubMed ID: 32879391
  • Yerukala Sathipati, Srinivasulu, Sahu, Divya, Huang, Hsuan-cheng, Lin, Ynching, Ho, Shinn-Ying. Identification and characterization of the lncRNA signature associated with overall survival in patients with neuroblastoma. Sci Rep. 2019 March 26; 5125 doi: 10.1038/s41598-019-41553-y. PMCID: PMC6435792.
    PubMed ID: 30914706
  • Yerukala Sathipati, Srinivasulu, Ho, Shinn-Ying. Identifying a miRNA signature for predicting the stage of breast cancer. Sci Rep. 2018 October 31; 16138 doi: 10.1038/s41598-018-34604-3. PMCID: PMC6208346.
    PubMed ID: 30382159
  • Yerukala Sathipati S, Huang HL, Ho SY. Estimating survival time of patients with glioblastoma multiforme and characterization of the identified microRNA signatures. BMC GENOMICS. 2016 December 22; 17(Suppl 13):1022. doi: 10.1186/s12864-016-3321-y. PMCID: PMC5260001.
    PubMed ID: 28155650
  • Yerukala Sathipati, Srinivasulu, Wang, Jyun-Rong, Hsu, Kai-Ti, Stai, Ming-Ju, Charoenkwan, Phasit, Huang, Wen-Lin,...Ho, Shinn-Ying. Characterizing informative sequence descriptors and predicting binding affinities of heterodimeric protein complexes. BMC BIOINFORMATICS. 2015 December 9; S14 doi: 10.1186/1471-2105-16-S18-S14. PMCID: PMC4682391.
    PubMed ID: 26681483
  • Liou, YiFan, Charoenkwan, Phasit, Yerukala Sathipati, Srinivasulu, Vasylenko,Tamara, Lai, Shih-Chung, Lee, Hua-Chin,...Ho, Shinn-Ying. SCMHBP: prediction and analysis of heme binding proteins using propensity scores of dipeptides. 2014 December 8; S4
  • Hui-Ling Huang, Yerukala Sathipati Srinivasulu, Phasit Charoenkwan, Hua-Chin Lee, Shinn-Ying Ho. Designing predictors of halophilic and non-halophilic proteins using support vector machines. 2013 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). 2013 April; doi: 10.1109/CIBCB.2013.6595414.