Tonia Carter PhD
Assoc. Research Scientist-Genetics
Center for Precision Medicine Research
1000 North Oak Ave. MLR Marshfield, WI 54449
- PhD, Epidemiology, University at Albany, State University of New York
- MS, Epidomiology, University at Albany, State University of New York
- MS, Mphil - Biochemistry, University of the West Indies, St. Augustine
- BS, BSc - Biochemistry, University of the West Indies, St. Augustine
- 2012 to Present:
- Project Scientist, Center for Human Genetics - Marshfield Clinic Research Institute, Marshfield
- 2007 to 2011:
- Postdoctoral Fellow, Eunice Kenndy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda
- 2002 to 2007:
- Research Scientist 1, Congenital Malformations Registry, New York State Department of Health, Troy
- 1999 to 2000:
- Graduate Research Assistant, Heavy Metals Registry, New York State Department of Health, Troy
- 1997 to 1999:
- Graduate Research Assistant, Wadsworth Center, New York State Department of Health, Albany
My main research interest is the mechanisms of birth defects. I use human genetics approaches to investigate how potentially damaging genetic variation can lead to birth defects.
Regulation of gene expression
Structural genetic variants
Koppel R, Druschel C, Carter TC, Goldberg B, Mehta P, Talwar R, Bierman F. (2003 March). Effectiveness of pulse oximetry screening for congenital heart disease in asymptomatic newborns. PEDIATRICS. 111(3):451-5.
PubMed ID: 12612220
Cleves M, Malik S, Yang S, Carter TC, Hobbs C. (2008 June). Maternal urinary tract infections and selected cardiovascular malformations. Birth Defects Res A Clin Mol Teratol. 82(6):464-73.
PubMed ID: 18452156
Carter TC, Druschel C, Romitti P, Bell E, Werler M, Mitchell A, National Birth Defects Prevention Study. (2008 February). Antifungal drugs and the risk of selected birth defects. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 198(2):191.
PubMed ID: 18226621
Carter TC, Molloy A, Pangilinan F, Troendle J, Kirke P, Conley M,...Mills J. (2010 February). Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. Birth Defects Res A Clin Mol Teratol. 88(2):84-93.
PubMed ID: 19937600
Mills J, Troendle J, Conley M, Carter TC, Druschel C. (2010 June). Maternal obesity and congenital heart defects: a population-based study. AMERICAN JOURNAL OF CLINICAL NUTRITION. 91(6):1543-9.
PubMed ID: 20375192
Carter TC, Olney R, Mitchell A, Romitti P, Bell E, Druschel C, National Birth Defects Prevention Study. (2011 February). Maternal self-reported genital tract infections during pregnancy and the risk of selected birth defects. Birth Defects Res A Clin Mol Teratol. 91(2):108-16.
PubMed ID: 21319278
Carter TC, Pangilinan F, Troendle J, Molloy A, VanderMeer J, Mitchell A,...Mills J. (2011 January). Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population. American Journal of Medical Genetics Part A. 155A(1):14-21.
PubMed ID: 21204206
Mills J, Carter TC, Scott J, Troendle J, Gibney E, Shane B,...Molloy A. (2011 August). Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status? AMERICAN JOURNAL OF CLINICAL NUTRITION. 94(2):495-500.
PubMed ID: 21653798
Mills J, Carter TC, Kay D, Browne M, Brody L, Liu AH,...Druschel C. (2012 May). Folate and vitamin B12-related genes and risk for omphalocele. HUMAN GENETICS. 131(5):739-46.
PubMed ID: 22116453
Browne ML, Carter TC, Kay DM, Kuehn D, Brody LC, Romitti PA,...Mills JL. (2012 October). Evaluation of genes involved in limb development, angiogenesis, and coagulation as risk factors for congenital limb deficiencies. Am J Med Genet A. 158A(10):2463-72.
PubMed ID: 22965740
Carter TC, Kay DM, Browne ML, Liu A, Romitti PA, Kuehn D,...Mills JL. (2012 August). Hirschsprung's disease and variants in genes that regulate enteric neural crest cell proliferation, migration and differentiation. J. Hum. Genet.. 57(8):485-93.
PubMed ID: 22648184
Carter TC, Kay DM, Browne ML, Liu A, Romitti PA, Kuehn D,...Mills JL. (2013 January). Anorectal atresia and variants at predicted regulatory sites in candidate genes. Ann. Hum. Genet.. 77(1):31-46.
PubMed ID: 23127126
Schrodi SJ, Mukherjee S, Shan Y, Tromp G, Sninsky JJ, Callear AP,...Weeks DE [including Carter TC, Ye Z, Brilliant MH.] (2014 June). Genetic-based prediction of disease traits: prediction is very difficult, especially about the future(†). Front Genet. 5 :162.
PubMed ID: 24917882
Ye Z, Vasco DA, Carter TC, Brilliant MH, Schrodi SJ, Shukla SK. (2014 May). Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections. Front Genet. 5 :125.
PubMed ID: 24847357
Fan R, Wang Y, Mills JL, Carter TC, Lobach I, Wilson AF,...Xiong M. (2014 November). Generalized functional linear models for gene-based case-control association studies. Genet Epidemiol. 38(7):622-637.
PubMed ID: 25203683
Carter TC, Pangilinan F, Molloy AM, Fan R, Wang Y, Shane B,...Mills JL. (2015 July). Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults. J Nutr. 145(7):1386-93.
PubMed ID: 25972531
Howley MM, Carter TC, Browne ML, Romitti PA, Cunniff CM, Druschel CM. (2016 May 27). Fluconazole use and birth defects in the National Birth Defects Prevention Study. Am J Obstet Gynecol. 214(5):657.
PubMed ID: 26640069
Carter TC, He MM. (2016). Challenges of Identifying Clinically Actionable Genetic Variants for Precision Medicine. J Healthc Eng. 2016
PubMed ID: 27195526
Carter TC, Rein D, Padberg I, Peter E, Rennefahrt U, David DE,...Schrodi SJ [including McManus V, Stefanski E.] (2016 September). Validation of a metabolite panel for early diagnosis of type 2 diabetes. Metab. Clin. Exp.. 65(9):1399-408.
PubMed ID: 27506746
Ailes EC, Gilboa SM, Gill SK, Broussard CS, Crider KS, Berry RJ,...Reefhuis J [including Carter TC.] (2016 November). Association between antibiotic use among pregnant women with urinary tract infections in the first trimester and birth defects, National Birth Defects Prevention Study 1997 to 2011. Birth Defects Res. Part A Clin. Mol. Teratol.. 106(11):940-949.
PubMed ID: 27891788
VanderMeer JE, Carter TC, Pangilinan F, Mitchell A, Kurnat-Thoma E, Kirke PN,...Brody LC. (2016 April). Evaluation of proton-coupled folate transporter (SLC46A1) polymorphisms as risk factors for neural tube defects and oral clefts. Am J Med Genet A. 170A(4):1007-16.
PubMed ID: 26789141
Carter TC, Sicko RJ, Kay DM, Browne ML, Romitti PA, Edmunds ZL,...Mills JL. (2017 October). Copy-number variants and candidate gene mutations in isolated split hand/foot malformation. J. Hum. Genet.. 62(10):877-884.
PubMed ID: 28539665
Carter TC, Hebbring SJ, Liu J, Mosley JD, Shaffer CM, Ivacic LC,...Belongia EA [including Kopitzke S, Stefanski EL, Strenn R, Meece J, Brilliant MH.] (2018 March). Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission. J. Med. Virol.. 90(3):436-446.
PubMed ID: 29053189