• Tonia Carter PhD

  • Assoc. Research Scientist-Genetics


    • Center for Precision Medicine Research
    • 1000 North Oak Ave. MLR Marshfield, WI 54449

Education


2007:
PhD, Epidemiology, University at Albany, State University of New York
2001:
MS, Epidomiology, University at Albany, State University of New York
1996:
MS, Mphil - Biochemistry, University of the West Indies, St. Augustine
1992:
BS, BSc - Biochemistry, University of the West Indies, St. Augustine

Work Experience


2012 to Present:
Project Scientist, Center for Human Genetics - Marshfield Clinic Research Institute, Marshfield
2007 to 2011:
Postdoctoral Fellow, Eunice Kenndy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda
2002 to 2007:
Research Scientist 1, Congenital Malformations Registry, New York State Department of Health, Troy
1999 to 2000:
Graduate Research Assistant, Heavy Metals Registry, New York State Department of Health, Troy
1997 to 1999:
Graduate Research Assistant, Wadsworth Center, New York State Department of Health, Albany

Statement


My main research interest is the mechanisms of birth defects. I use human genetics approaches to investigate how potentially damaging genetic variation can lead to birth defects.

Research Interests


Birth defects
Human genetics
Functional genomics
Regulation of gene expression
Structural genetic variants

Select Publications


  • Koppel R, Druschel C, Carter TC, Goldberg B, Mehta P, Talwar R, Bierman F. (2003 March). Effectiveness of pulse oximetry screening for congenital heart disease in asymptomatic newborns. PEDIATRICS. 111(3):451-5.
    PubMed ID: 12612220
  • Cleves M, Malik S, Yang S, Carter TC, Hobbs C. (2008 June). Maternal urinary tract infections and selected cardiovascular malformations. Birth Defects Res A Clin Mol Teratol. 82(6):464-73.
    PubMed ID: 18452156
  • Carter TC, Druschel C, Romitti P, Bell E, Werler M, Mitchell A, National Birth Defects Prevention Study. (2008 February). Antifungal drugs and the risk of selected birth defects. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 198(2):191.
    PubMed ID: 18226621
  • Carter TC, Molloy A, Pangilinan F, Troendle J, Kirke P, Conley M,...Mills J. (2010 February). Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. Birth Defects Res A Clin Mol Teratol. 88(2):84-93.
    PubMed ID: 19937600
  • Mills J, Troendle J, Conley M, Carter TC, Druschel C. (2010 June). Maternal obesity and congenital heart defects: a population-based study. AMERICAN JOURNAL OF CLINICAL NUTRITION. 91(6):1543-9.
    PubMed ID: 20375192
  • Carter TC, Olney R, Mitchell A, Romitti P, Bell E, Druschel C, National Birth Defects Prevention Study. (2011 February). Maternal self-reported genital tract infections during pregnancy and the risk of selected birth defects. Birth Defects Res A Clin Mol Teratol. 91(2):108-16.
    PubMed ID: 21319278
  • Carter TC, Pangilinan F, Troendle J, Molloy A, VanderMeer J, Mitchell A,...Mills J. (2011 January). Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population. American Journal of Medical Genetics Part A. 155A(1):14-21.
    PubMed ID: 21204206
  • Mills J, Carter TC, Scott J, Troendle J, Gibney E, Shane B,...Molloy A. (2011 August). Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status? AMERICAN JOURNAL OF CLINICAL NUTRITION. 94(2):495-500.
    PubMed ID: 21653798
  • Mills J, Carter TC, Kay D, Browne M, Brody L, Liu AH,...Druschel C. (2012 May). Folate and vitamin B12-related genes and risk for omphalocele. HUMAN GENETICS. 131(5):739-46.
    PubMed ID: 22116453
  • Browne ML, Carter TC, Kay DM, Kuehn D, Brody LC, Romitti PA,...Mills JL. (2012 October). Evaluation of genes involved in limb development, angiogenesis, and coagulation as risk factors for congenital limb deficiencies. Am J Med Genet A. 158A(10):2463-72.
    PubMed ID: 22965740
  • Carter TC, Kay DM, Browne ML, Liu A, Romitti PA, Kuehn D,...Mills JL. (2012 August). Hirschsprung's disease and variants in genes that regulate enteric neural crest cell proliferation, migration and differentiation. J. Hum. Genet.. 57(8):485-93.
    PubMed ID: 22648184
  • Carter TC, Kay DM, Browne ML, Liu A, Romitti PA, Kuehn D,...Mills JL. (2013 January). Anorectal atresia and variants at predicted regulatory sites in candidate genes. Ann. Hum. Genet.. 77(1):31-46.
    PubMed ID: 23127126
  • Schrodi SJ, Mukherjee S, Shan Y, Tromp G, Sninsky JJ, Callear AP,...Weeks DE [including Carter TC, Ye Z, Brilliant MH.] (2014 June). Genetic-based prediction of disease traits: prediction is very difficult, especially about the future(†). Front Genet. 5 :162.
    PubMed ID: 24917882
  • Ye Z, Vasco DA, Carter TC, Brilliant MH, Schrodi SJ, Shukla SK. (2014 May). Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections. Front Genet. 5 :125.
    PubMed ID: 24847357
  • Fan R, Wang Y, Mills JL, Carter TC, Lobach I, Wilson AF,...Xiong M. (2014 November). Generalized functional linear models for gene-based case-control association studies. Genet Epidemiol. 38(7):622-637.
    PubMed ID: 25203683
  • Carter TC, Pangilinan F, Molloy AM, Fan R, Wang Y, Shane B,...Mills JL. (2015 July). Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults. J Nutr. 145(7):1386-93.
    PubMed ID: 25972531
  • Howley MM, Carter TC, Browne ML, Romitti PA, Cunniff CM, Druschel CM. (2016 May 27). Fluconazole use and birth defects in the National Birth Defects Prevention Study. Am J Obstet Gynecol. 214(5):657.
    PubMed ID: 26640069
  • Carter TC, He MM. (2016). Challenges of Identifying Clinically Actionable Genetic Variants for Precision Medicine. J Healthc Eng. 2016
    PubMed ID: 27195526
  • Carter TC, Rein D, Padberg I, Peter E, Rennefahrt U, David DE,...Schrodi SJ [including McManus V, Stefanski E.] (2016 September). Validation of a metabolite panel for early diagnosis of type 2 diabetes. Metab. Clin. Exp.. 65(9):1399-408.
    PubMed ID: 27506746
  • Ailes EC, Gilboa SM, Gill SK, Broussard CS, Crider KS, Berry RJ,...Reefhuis J [including Carter TC.] (2016 November). Association between antibiotic use among pregnant women with urinary tract infections in the first trimester and birth defects, National Birth Defects Prevention Study 1997 to 2011. Birth Defects Res. Part A Clin. Mol. Teratol.. 106(11):940-949.
    PubMed ID: 27891788
  • VanderMeer JE, Carter TC, Pangilinan F, Mitchell A, Kurnat-Thoma E, Kirke PN,...Brody LC. (2016 April). Evaluation of proton-coupled folate transporter (SLC46A1) polymorphisms as risk factors for neural tube defects and oral clefts. Am J Med Genet A. 170A(4):1007-16.
    PubMed ID: 26789141
  • Carter TC, Sicko RJ, Kay DM, Browne ML, Romitti PA, Edmunds ZL,...Mills JL. (2017 October). Copy-number variants and candidate gene mutations in isolated split hand/foot malformation. J. Hum. Genet.. 62(10):877-884.
    PubMed ID: 28539665
  • Carter TC, Hebbring SJ, Liu J, Mosley JD, Shaffer CM, Ivacic LC,...Belongia EA [including Kopitzke S, Stefanski EL, Strenn R, Meece J, Brilliant MH.] (2018 March). Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission. J. Med. Virol.. 90(3):436-446.
    PubMed ID: 29053189