• Robert Valenzuela PhD

  • Biostatistician/Bioinformatician


    • Center for Precision Medicine Research
    • 1000 North Oak Ave. MLR Marshfield, WI 54449

Education


2011:
PhD, Genetics, University of Arizona, Tucson, AZ
2001:
MS, Biology, Northern Arizona University, Flagstaff, AZ
1995:
BS, Physics, Arizona State University, Tempe, AZ

Work Experience


2018 to Present:
Biostatistician/Bioinformatician, Marshfield Clinic Research Institute, Marshfield, WI
2017 to 2018:
Biostatistician/Bioinformatician (Consultant), Asia Genomics, Singapore
2012 to 2017:
Postdoctoral Research Assistant, Genome Institute of Singapore, Singapore
2012 to 2012:
Postdoctoral Research Assistant, The Jackson Laboratory, Bar Harbor, ME
2011 to 2012:
Postdoctoral Research Assistant, Marshfield Clinic Research Foundation, Marshfield, WI
2009 to 2011:
Graduate Research Assistant, Marshfield Clinic Research Foundation, Marshfield, WI
2005 to 2009:
Graduate Teaching/Research Assistant, University of Arizona, Tucson, AZ
2005 to 2005:
Predoctoral fellowship, Lab Technician, National Institute of Health, Phoenix, AZ
2002 to 2003:
Geneticist (GS-0440-09), United States Geological Survey, Anchorage, AK
1998 to 2001:
Graduate Research Assistant, Northern Arizona University, Flagstaff, AZ

Statement


My research focus is to elucidate the genetic architecture of a complex trait and to remain at the cutting-edge of genomics through the utilization of novel sequencing technologies and bioinformatics tools.

Research Interests


Genetic architecture
Genomics
Novel sequencing technologies
Boinformatics

Select Publications


  • Service PM, Ochoa R, Valenzuela R, Michieli CA. (1998 Jun). Cohort size and maximum likelihood estimation of mortality parameters. Exp. Gerontol.. 33(4):331-42.
    PubMed ID: 9639169
  • Valenzuela RK, Forbes SN, Keim P, Service PM. (2004 Sep). Quantitative trait loci affecting life span in replicated populations of Drosophila melanogaster. II. Response to selection. Genetics. 168(1):313-24.
    PubMed ID: 15454545
  • Forbes SN, Valenzuela RK, Keim P, Service PM. (2004 Sep). Quantitative trait loci affecting life span in replicated populations of Drosophila melanogaster. I. Composite interval mapping. Genetics. 168(1):301-11.
    PubMed ID: 15454544
  • Nielsen JL, Valenzuela R, Wiacek T, Byrne A, Graziano S. (2004). Idaho Fish and Game, Fisheries Technical Reports. 138(article 2)
  • Erickson RP, Larson-Thomé K, Valenzuela RK, Whitaker SE, Shub MD. (2008 Dec 15). Navajo microvillous inclusion disease is due to a mutation in MYO5B. Am. J. Med. Genet. A. 146A(24):3117-9.
    PubMed ID: 19006234
  • Valenzuela RK, Henderson MS, Walsh MH, Garrison NA, Kelch JT, Cohen-Barak O,...Brilliant MH. (2010 Mar). Predicting phenotype from genotype: normal pigmentation. JOURNAL OF FORENSIC SCIENCES. 55(2):315-22.
    PubMed ID: 20158590
  • Ito S, Nakanishi Y, Valenzuela RK, Brilliant MH, Kolbe L, Wakamatsu K. (2011 Aug). Usefulness of alkaline hydrogen peroxide oxidation to analyze eumelanin and pheomelanin in various tissue samples: application to chemical analysis of human hair melanins. Pigment Cell Melanoma Res. 24(4):605-13.
    PubMed ID: 21535429
  • Valenzuela RK, Ito S, Wakamatsu K, Brilliant MH. (2011 Oct 29). Prediction Model Validation: Normal Human Pigmentation Variation. J Forensic Res. 2 :139-151.
  • Zhang R, Valenzuela RK, Lu S, Meng L, Guo T, Du X,...Ma J. (2011 Dec). Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. Schizophr. Res.. 133(1-3):159-64.
    PubMed ID: 21993378
  • Zhong N, Zhang R, Qiu C, Yan H, Valenzuela RK, Zhang H,...Ma J. (2011 Feb 4). A novel replicated association between FXYD6 gene and schizophrenia. Biochem. Biophys. Res. Commun.. 405(1):118-21.
    PubMed ID: 21216238
  • Zhang R, Lu SM, Qiu C, Liu XG, Gao CG, Guo TW,...Ma J. (2011 Apr). Population-based and family-based association studies of ZNF804A locus and schizophrenia. Mol. Psychiatry. 16(4):360-1.
    PubMed ID: 20458322
  • Tuli AM, Valenzuela R, Kamugisha E, Brilliant MH. (2012 Dec). Albinism and disease causing pathogens in Tanzania: are alleles that are associated with OCA2 being maintained by balancing selection? MEDICAL HYPOTHESES. 79(6):875-8.
    PubMed ID: 23063908
  • Zhang R, Yan JD, Valenzuela RK, Lu SM, Du XY, Zhong B,...Ma J. (2012 Oct). Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. Schizophr. Res.. 141(1):40-7.
    PubMed ID: 22871346
  • Li D, Du X, Zhang R, Shen B, Huang Y, Valenzuela RK,...Ma J. (2012 Apr). Mutation identification of the DSPP in a Chinese family with DGI-II and an up-to-date bioinformatic analysis. Genomics. 99(4):220-6.
    PubMed ID: 22310900
  • Zhang R, Lu S, Meng L, Min Z, Tian J, Valenzuela RK,...Ma J. (2012). Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. PLoS ONE. 7(1):e30237.
    PubMed ID: 22276163
  • Ma J, Lan X, Gao N, Wang J, Hao D, Yao J,...Valenzuela RK. (2013 Oct 30). A genetic association study between common variants in the ABCA13 gene and schizophrenia in a Han Chinese population. Psychiatry Res. 209(3):748-9.
    PubMed ID: 23910238
  • Zhang R, Zhang H, Li M, Li H, Li Y, Valenzuela RK,...Ma J. (2013 Oct 1). Genetic analysis of common variants in the CMYA5 (cardiomyopathy-associated 5) gene with schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry. 46 :64-9.
    PubMed ID: 23778016
  • Liu X, Gao L, Zhao A, Zhang R, Ji B, Wang L,...Ma J. (2014). Identification of duplication downstream of BMP2 in a Chinese family with brachydactyly type A2 (BDA2). PLoS ONE. 9(4):e94201.
    PubMed ID: 24710560
  • Nie F, Wang X, Zhao P, Yang H, Zhu W, Zhao Y,...Ma J. (2015 Dec). Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive meta-analysis. Am. J. Med. Genet. B Neuropsychiatr. Genet.. 168(8):637-48.
    PubMed ID: 26227746
  • Zhang J, Ma J, Du X, Wu D, Ai H, Bai J,...Liu C. (2015 Jan 5). Clinical and genetic investigation of a multi-generational Chinese family afflicted with Von Hippel-Lindau disease. Chin. Med. J.. 128(1):32-8.
    PubMed ID: 25563310
  • Wu S, Zhang R, Nie F, Wang X, Jiang C, Liu M,...Ma J. (2016 Oct). MicroRNA-137 Inhibits EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients. EBioMedicine. 12 :133-142.
    PubMed ID: 27650867
  • Chua SY, Sabanayagam C, Cheung YB, Chia A, Valenzuela RK, Tan D,...Saw SM. (2016 Jul). Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children. Ophthalmic Physiol Opt. 36(4):388-94.
    PubMed ID: 27350183