• Steve Schrodi PhD

  • Assoc. Research Scientist-Genetics


    • Center for Precision Medicine Research
    • 1000 North Oak Ave. MLR Marshfield, WI 54449

Education


2001:
PhD, Biological Sciences, Laboratory of Walter M. Fitch, University of California, Irvine
1998:
MS, Biological Sciences, Laboratory of Richard R. Hudson, University of California, Irvine
1995:
BS, Genetics, University of California, Davis
1992:
Research Internship, Theoretical Space Science Division, NASA Ames Research Center

Work Experience


2015 to Present:
Associate Editor, Frontiers in Genetics
2013 to Present:
Faculty Trainer, Computation and Informatics in Biology and Medicine, University of Wisconsin, Madison
2010 to Present:
Tenure-Track Associate Research Scientist, Center for Human Genetics - Marshfield Clinic Research Institute, Marshfield
2010 to Present:
Member, University of Wisconsin Institute for Clinical and Translational Research, Madison
2008 to 2010:
Senior Staff Scientist, Celera , Alameda, CA
2006 to 2008:
Staff Scientist, Celera , Alameda, CA
2001 to 2006:
Senior Scientist, Celera , Alameda, CA
2000 to 2001:
Scientist, DNA Sciences, Fremont, CA

Honors & Awards


1992:
Excellence in Research Award, NASA Ames Research Center
2004:
Top 10 Arthritis Advances of 2004 - Arthritis Foundation
2005:
UCSF Frontiers in Neurology & Neuroscience, Key Speaker
2007:
Applera Demonstrated Noteworthy Achievement Award
2010:
US Patent 7,833,706; Inventor
2011:
US Patent 7,863,021; Inventor
2011:
US Patent 7,947,451; Inventor
2011:
US Patent 7,993,833; Inventor
2015:
US Patent 8,975,022; Inventor
2016:
US Patent 9,371,565; Inventor
2016:
Mathematics, Statistics and Computer Science Colloquium Speaker, Marquette University

Statement


My primary areas of research lie in complex disease genetics, the development of disease genetics theory, and the construction of novel statistical genetics methods.

Research Interests


Human Genetics
Disease Genetics Theory
Bayesian Statistics and Applied Probability
Systemic Inflammation Traits
Autoimmune Genetics
Predictive Modeling

Professional Societies


Member - International Society of Bayesian Analysis
Member - American Society of Human Genetics
Scientific Advisory Board: DNA Sciences
Statistical Genetics Consultant

Committees


New England Journal of Medicine, Ad hoc Reviewer
Nature, Ad hoc Reviewer
Journal Investigative Dermatology, Ad hoc Reviewer
Genes and Immunity, Ad hoc Reviewer
American Naturalist, Ad hoc Reviewer
Genetics, Ad hoc Reviewer
Arthritis and Rheumatism, Ad hoc Reviewer
Annals of Neurology, Ad hoc Reviewer
Computational Statistics and Data Analysis, Ad hoc Reviewer

Select Publications


  • Bansal NK, Maadooliat M, Schrodi SJ. (2018 Jul 5). Empirical Bayesian approach to testing multiple hypotheses with separate priors for left and right alternatives. Stat Appl Genet Mol Biol.
    PubMed ID: 29975669
  • Schrodi SJ. (2017 January 17). Postmortem Genetic Testing for Sudden Unexpected Death. JAMA. 317(3):320-21.
    PubMed ID: 28114545
  • Liu Y, Ye Z, Li X, Anderson JL, Khan M, DaSilva D,...Smith JA [including Wilson D, Bocoun V, Ivacic LC, Schrodi SJ.] (2017). Genetic and Functional Associations with Decreased Anti-inflammatory Tumor Necrosis Factor Alpha Induced Protein 3 in Macrophages from Subjects with Axial Spondyloarthritis. Front Immunol. 8 :860.
    PubMed ID: 28791018
  • Schotthoefer AM, Schrodi SJ, Meece JK, Fritsche TR, Shukla SK. (2017). Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis. PLoS One. 12(6):e0179655.
    PubMed ID: 28628633
  • Schrodi SJ. (2017 October 18). The Impact of Diagnostic Code Misclassification on Optimizing the Experimental Design of Genetic Association Studies. J Healthc Eng. 2017 :7653071.
    PubMed ID: 29181145
  • Schrodi SJ. (2016). The Use of Multiplicity Corrections, Order Statistics and Generalized Family-Wise Statistics with Application to Genome-Wide Studies. PLoS One. 11(4):e0154472.
    PubMed ID: 27128491
  • Schrodi SJ. (2016). Reflections on the Field of Human Genetics: A Call for Increased Disease Genetics Theory. Front Genet. 7 :106.
    PubMed ID: 27375680
  • Tokarz SA, DeValk J, Luo W, Pattnaik BR, Schrodi SJ, Pillers DA. (2016 July). Cell line donor genotype and its influence on experimental phenotype: Toll-like receptor SNPs and potential variability in innate immunity. Mol Genet Metab. 118(3):147-52.
    PubMed ID: 27324283
  • Carter TC, Rein D, Padberg I, Peter E, Rennefahrt U, David DE,...Schrodi SJ [including McManus V, Stefanski E.] (2016 September). Validation of a metabolite panel for early diagnosis of type 2 diabetes. Metab. Clin. Exp.. 65(9):1399-408.
    PubMed ID: 27506746
  • Brilliant MH, Vaziri K, Connor TB, Schwartz SG, Carroll JJ, McCarty CA,...McKay BS [including Schrodi SJ.] (2016 March). Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. Am J Med. 129(3):292-8.
    PubMed ID: 26524704
  • Maadooliat M, Bansal NK, Upadhya J, Farazi MR, Li X, He MM,...Schrodi SJ [including Hebbring SJ, Ye Z.] (2016 December 12). The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem. Front Genet. 7 :217.
    PubMed ID: 28018425
  • Ye Z, Mayer JG, Ivacic LC, Zhou Z, He M, Schrodi SJ,...Hebbring S [including Brilliant MH.] (2015 April). Phenome-wide association studies (PheWASs) for functional variants. Eur J Hum Genet. 23(4):523-9.
    PubMed ID: 25074467
  • Schrodi SJ, Debarber A, He M, Ye Z, Peissig PL, VanWormer JJ,...Steiner R [including Haws RM., Brilliant MH.] (2015 June). Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data. Hum Genet. 134(6):659-69.
    PubMed ID: 25893794
  • O'Brien S, Schrodi SJ, Brilliant MH, Virani S, Brautbar A. (2015 August). Differential Lipid Response to Statins is Associated with Variants in the BUD13-APOA5 Gene Region. J Cardiovasc Pharmacol.. 66(2):183-8..
    PubMed ID: 25900265
  • Shukla SK, Rose W, Schrodi SJ. (2015 June). Complex host genetic susceptibility to Staphylococcus aureus infections. Trends Microbiol.. :pii: S0966-842X(15)00128-6.
    PubMed ID: 26112911
  • He M, Person TN, Hebbring S, Heinzen E, Ye Z, Schrodi SJ,...Wang K [including McPherson EW, Peissig PL, Brilliant MH.] (2015 April). SeqHBase: a big data toolset for family based sequencing data analysis. JOURNAL OF MEDICAL GENETICS. 52(4):282-8.
    PubMed ID: 25587064
  • Shukla SK, Cook D, Meyer J, Vernon SD, Le T, Clevidence D,...Frank DN [including Schrodi SJ.] (2015). Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). PLoS One. 10(12):e0145453.
    PubMed ID: 26683192
  • Schrodi SJ, Jones HB. (2015 September 2). Calculating Exact P-Values from the McNamara Transmission/Disequilibrium Test Statistic. Journal of Investigative Genomics. 2(4):00032.
  • Schrodi SJ, Mukherjee S, Shan Y, Tromp G, Sninsky JJ, Callear AP,...Weeks DE [including Carter TC, Ye Z, Brilliant MH.] (2014 June). Genetic-based prediction of disease traits: prediction is very difficult, especially about the future(†). Front Genet. 5 :162.
    PubMed ID: 24917882
  • Ye Z, Vasco DA, Carter TC, Brilliant MH, Schrodi SJ, Shukla SK. (2014 May). Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections. Front Genet. 5 :125.
    PubMed ID: 24847357
  • Mayer J, Kitchner T, Ye Z, Zhou Z, He M, Schrodi SJ, Hebbring SJ. (2014 December). Use of an electronic medical record to create the marshfield clinic twin/multiple birth cohort. Genet Epidemiol. 38(8):692-8.
    PubMed ID: 25250975
  • Hebbring S, Slager S, Epperla N, Mazza JJ, Ye Z, Zhou Z,...Schrodi SJ [including Vasco DA, Brilliant MH.] (2013 January). Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. BLOOD. 121(1):237-8.
    PubMed ID: 23287625
  • Hebbring S, Schrodi SJ, Ye Z, Zhou Z, Page D, Brilliant MH. (2013 April). A PheWAS approach in studying HLA-DRB1*1501 GENES AND IMMUNITY. 14(3):187-91.
    PubMed ID: 23392276
  • Schrodi, SJ. (2012). Genomics/Phenomics/Proteomics/Translational Research. In: Powell, V, Din, FM, Acharya, A, Torres-Urquidy, MH (Ed.), Integration of Medical and Dental Care and Patient Data. (pp. 252-268). London, United Kingdom: Springer.
  • Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F,...Schrodi S. (2012 December). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 44(12):1341-8.
    PubMed ID: 23143594
  • Duffin KC, Freeny IC, Schrodi SJ, Wong B, Feng BJ, Soltani-Arabshahi R,...Krueger GG. (2009 December). Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking. J Invest Dermatol. 129(12):2777-83.
    PubMed ID: 19554022
  • Feng BJ, Sun LD, Soltani-Arabshahi R, Bowcock AM, Nair RP, Stuart P,...Goldgar DE. (2009 August). Multiple Loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet. 5(8):e1000606.
    PubMed ID: 19680446
  • Li Y, Liao W, Chang M, Schrodi SJ, Bui N, Catanese JJ,...Begovich AB. (2009 March). Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. Invest Dermatol. 129(3):629-34.
    PubMed ID: 18923449
  • Nair RP, Duffin KC, Helms C, Ding J, Stuart P, Goldgar DE,...Collaborative Association Study of Psoriasis. (2009 February). Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. NATURE GENETICS. 41(2):199-204.
    PubMed ID: 19169254
  • Schrodi SJ. (2008 September). Genome-wide association scan in psoriasis: new insights into chronic inflammatory disease. Expert Rev Clin Immunol. 4(5):565-71.
    PubMed ID: 20476959
  • Garcia VE, Chang M, Brandon R, Li Y, Matsunami N, Callis-Duffin KP,...Schrodi SJ. (2008 September). Detailed genetic characterization of the interleukin-23 receptor in psoriasis. Genes Immun. 9(6):546-55.
    PubMed ID: 18650833
  • Chang M, Rowland CM, Garcia VE, Schrodi SJ, Catanese JJ, van der Helm-van Mil AH,...Begovich AB. (2008 June). A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2. PLoS Genet.. 4(6):e1000107.
    PubMed ID: 18648537
  • Li Y, Rowland CM, Xiromerisiou G, Lagier RJ, Schrodi SJ, Dradiotis E,...Hadjigeorgiou G. (2008 July). Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. PLoS One. 3(7):e2707.
    PubMed ID: 18628988
  • Li Y, Chang M, Schrodi SJ, Callis-Duffin KP, Matsunami N, Civello D,...Begovich AB. (2008 October). The 5q31 variants associated with psoriasis and Crohn's disease are distinct. Hum Mol Genet. 17(19):2978-85.
    PubMed ID: 18614543
  • Chang M, Saiki RK, Catanese JJ, Lew D, van der Helm-van Mil AH, Toes RE,...Begovich AB. (2008 June). The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis. Arthritis Rheum. 58(6):1877-81.
    PubMed ID: 18512797
  • Chang M, Li Y, Yan C, Callis-Duffin KP, Matsunami N, Garcia VE,...Schrodi SJ. (2008 March). Variants in the 5q31 cytokine gene cluster are associated with psoriasis. Genes Immun. 9(2):176-81.
    PubMed ID: 18075513
  • Kurreeman FA, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, Stoeken-Rijsbergen G,...Toes RE. (2007 September). A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis. PLoS Med. 4(9):e278.
    PubMed ID: 17880261
  • Begovich AB, Chang M, Schrodi SJ. (2007 September). Meta-analysis evidence of a differential risk of the FCRL3 -169T-->C polymorphism in white and East Asian rheumatoid arthritis patients. Arthritis Rheum. 56(9):3168-71.
    PubMed ID: 17763442
  • Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis-Duffin KP,...Begovich AB. (2007 February). A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 80(2):273-90.
    PubMed ID: 17236132
  • Schrodi SJ, Garcia VE, Rowland CM, Jones HB. (2007 February). Pairwise linkage disequilibrium under disease models. Eur J Hum Genet. 15(2):212-20.
    PubMed ID: 17106449
  • Schrodi SJ, Chang M, Garcia VE, Civello D, Jacobson A, van der Helm-van Mil AH,...Begovich AB. (2007). A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2. Celera Report.
  • Huang H, Shiffman ML, Cheung RC, Layden TJ, Friedman SL, Abar OT,...Wright TL. (2006 May). Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. Gastroenterology. 130(6):1679-87.
    PubMed ID: 16697732
  • Li Y, Schrodi SJ, Rowland CM, Tacey K, Catanese JJ, Grupe A. (2006 October). Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. Hum Mutat. 27(10):1017-23.
    PubMed ID: 16917932
  • Li Y, Rowland CM, Schrodi SJ, Laird W, Tacey K, Ross DA,...Grupe A. (2006 June). A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan. Am J Hum Genet. 78(6):1090-2; author reply 1092-4.
    PubMed ID: 16685663
  • Schrodi SJ. (2005). A probabilistic approach to large-scale association scans: a semi-Bayesian method to detect disease-predisposing alleles. Stat Appl Genet Mol Biol. 4(1):Article 31.
    PubMed ID: 16646850
  • Carlton VE, Hu X, Chokkalingam AP, Schrodi SJ, Brandon R, Alexander HR,...Begovich AB. (2005 October). PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet. 77(4):567-81.
    PubMed ID: 16175503
  • Li Y, Tacey K, Doil L, van Luchene R, Garcia VE, Rowland CM,...Grupe A. (2004 August). Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study. Neurosci Lett. 366(3):268-71.
    PubMed ID: 15288432
  • Hu X, Schrodi SJ, Ross DA, Cargill M. (2004). Selecting tagging SNPs for association studies using power calculations from genotype data. Hum Hered. 57(3):156-70.
    PubMed ID: 15297809
  • Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HR,...Gregersen PK. (2004 August). A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet. 75(2):330-7.
    PubMed ID: 15208781
  • Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL,...Grupe A. (2004 November). Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci U S A. 101(44):15688-93.
    PubMed ID: 15507493
  • Schrodi SJ. (2001). A modification to the standard model of haploid population genetics for small population sizes. Mathematical models in population genetics, molecular evolution and genomics. Ann Arbor, MI:: UMI dissertation services;.
  • Schrodi SJ. (2001). Substitution variability under neutrality. A modification to the standard model of haploid population genetics for small population sizes. Ann Arbor, MI:: UMI dissertation services;.
  • Schrodi SJ. (2001). Increasing dispersion index for mammalian sequences. A modification to the standard model of haploid population genetics for small population sizes. Ann Arbor, MI:: UMI dissertation services;.