Marshfield Clinic Research Institute is organized into six research Centers.

Clinical Research Center supports approximately 450 clinical trials (drug, device and therapy) for multispecialty and oncology, as well as other patient oriented research.

Cancer Care and Research Center provides Marshfield Clinic Health System patients access to more than 100 state of the art treatment, cancer control and precision oncology clinical trials at most Health System locations. 

National Farm Medicine Center is one of the longest-running and most successful agricultural health and safety research centers in the country.

Center for Clinical Epidemiology and Population Health contributes to medical and scientific knowledge through population-based and other epidemiologic research, and its studies have led both to improved medical care and more effective public health policies. 

Center for Precision Medicine Research continues to advance knowledge of the structure of the human genome and the genetic basis of complex diseases, while expanding in the fields of genetic epidemiology, pharmacogenetics, population genetics and the clinical implementation of genomic medicine. It conducts cutting edge biomedical research and translates scientific discoveries into clinical and dental practice through innovation, education, collaboration and application of informatics best practices.

Center for Oral and Systemic Health focuses on oral and systemic health related research. It has five core units: Oral Health Informatics, Dental Public Health, Oral Biology, Dental Clinical Research and Educational core.